Poster: GB004 Exhibits Protective Effects Directly on Epithelial Cells Using Ex Vivo Organoid and Monolayer Cultures

• DA

• November 24, 2023

• Edited 10 months ago

Client Kristin Taylor Meadows and colleagues from Gossamer Bio used RepliGut® Planar to establish conditions for inducing inflammation response using TNFα. Using this model, they demonstrated GB004 protective effects, showing how GB-004, a novel compound in development for treating ulcerative colitis, can reduce the destructive effects of TNFα on epithelial barrier integrity.