# www.altisbiosystems.com

> AI-optimized mirror of www.altisbiosystems.com containing 50 pages totalling 6,347 words of clean markdown content, structured data, and semantic HTML. Original source: https://www.altisbiosystems.com/. Last updated: 2026-05-17T20:04:58.022Z.

Each page is available as HTML (with JSON-LD structured data) and Markdown (text-only, ideal for LLMs and RAG).

## Homepage

- [Capturing the Complexity of the Human Gut](/site-root.html): Our goal is to enable pharmaceutical companies to identify effective compounds earlier, before clinical trials; to reduce animal testing (829 words)

## Articles & Blog Posts

- [How Does Altis Biosystems Envision the Future of the Pharma/Biopharma Industry?](/how-does-altis-biosystems-envision-the-future-of-the-pharma-biopharma-industry.html): Altis Biosystems shares insights on the future of pharma and biopharma—focusing on innovation, human-relevant models, and next-gen drug development. (773 words)
- [Custom Services](/services/index.html): Whether you know exactly what you want, or need our consultation, our PhD level project leads are there to help you use RepliGut models to their fullest. (515 words)
- [GI Toxicity Services](/stemtox-info-b/index.html): Discover a robust new way to predict GI side effects in your program (227 words)
- [GI Toxicity Services](/stemtox-info-a/index.html): Discover a robust new way to predict GI side effects in your program (202 words)
- [Altis Biosystems Appoints Jimmy Smedley, Ph.D. Chief Operating Officer](/jimmy-smedley-altis-coo/index.html): Altis Biosystems appoints Jimmy Smedley as COO to lead operations and expand RepliGut® platform and preclinical service offerings. (284 words)
- [Manuscript: NSAID-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells](/nsaid-induced-leaky-gut-model/index.html): RepliGut® models NSAID-induced leaky gut, showing barrier disruption and inflammation in primary human intestinal epithelial monolayers. (125 words)
- [Poster: Primary Human Small Intestine Monolayers For Assessing Drug-Induced Intestinal Liabilities In Vitro](/sot-2023-repligut-poster/index.html): RepliGut SOT 2023 poster showcases cytokine response, barrier function, and inflammation modeling in human intestinal epithelial systems. (133 words)
- [Poster: A primary jejunum and primary hepatocyte multi-organ MPS: a promising tool for more predictive studies of human drug ADME and oral bioavailability](/issx-dmdg-repligut-poster-2023/index.html): ISSX DMDG poster showcases RepliGut® for modeling intestinal barrier integrity and permeability in human-relevant in vitro systems. (137 words)
- [Manuscript: Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human Intestinal Epithelial Monolayer Platform](/analysis-of-interleukin-8-secretion/index.html): Discover how interleukin-8 secretion analysis helps measure cytokines in stem cell-derived intestinal epithelium exposure to TNFa. (138 words)
- [Thank you for submitting your message](/thank-you/index.html) (41 words)
- [Manuscript: Evaluation of human primary intestinal monolayers for drug metabolizing capabilities](/evaluation-of-human-primary-intestinal-monolayers/index.html): RepliGut® human primary intestinal monolayers support barrier integrity, drug response, and inflammation modeling in preclinical research. (153 words)
- [Poster: GB004 Exhibits Protective Effects Directly on Epithelial Cells Using Ex Vivo Organoid and Monolayer Cultures](/gb004-exhibits-protective-effects-directly/index.html): Study shows GB004 protective effects on gut epithelium using RepliGut®, supporting barrier function and activating the Wnt pathway in preclinical models. (118 words)
- [Poster: Characterization of a novel human primary intestinal epithelial monolayer platform in response to a cytokine challenge](/characterization-of-a-novel-human-primary/index.html): Learn how Altis Biosystems is advancing drug development with a novel human primary intestinal model—engineered for reproducibility, barrier function studies, and human-relevant preclinical research. (147 words)
- [A Sensitive and Specific Human Primary Stem Cell-Based In Vitro Assay for Predicting The Gastrointestinal Toxicity Risk of Therapeutic Agents - Altis Biosystems](/case-studies-for-lit/a-sensitive-and-specific-human-primary-stem-cell-based-in-vitro-assay-for-predicting-the-gastrointestinal-toxicity-risk-of-therapeutic-agents.html) (35 words)
- [Manuscript: Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells](/self-renewing-intestinal-monolayer-a-breakthrough-study.html): Understand the importance of the self-renewing intestinal monolayer in regenerative medicine as outlined by Dr. Yuli Wang and colleagues. (97 words)
- [Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells - Altis Biosystems](/case-studies-for-lit/self-renewing-monolayer-of-primary-colonic-or-rectal-epithelial-cells.html) (35 words)
- [Manuscript: Evaluation of human primary intestinal monolayers for drug metabolizing capabilities - Altis Biosystems](/case-studies-for-lit/manuscript-evaluation-of-human-primary-intestinal-monolayers-for-drug-metabolizing-capabilities.html) (35 words)
- [Manuscript: NSAID-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. - Altis Biosystems](/case-studies-for-lit/manuscript-nsaid-induced-leaky-gut-modeled-using-polarized-monolayers-of-primary-human-intestinal-epithelial-cells.html) (35 words)
- [Poster: Studying the Complex Intestinal Mucus – Microbiome Nexus Using Sterile Human Mucus Harvested from RepliGut® Planar.  - Altis Biosystems](/case-studies-for-lit/poster-studying-the-complex-intestinal-mucus-microbiome-nexus-using-sterile-human-mucus-harvested-from-repligut-planar.html) (35 words)
- [Poster: The Development of Human Primary Culture Systems to Model - Altis Biosystems](/case-studies-for-lit/poster-the-development-of-human-primary-culture-systems-to-model.html) (35 words)
- [Poster: A Novel Approach to Harvest Human Mucus on RepliGut® Planar Platform for Research Related to Gastrointestinal Tract and Its Associated Disorders, along with Drug Delivery Studies.  - Altis Biosystems](/case-studies-for-lit/poster-a-novel-approach-to-harvest-human-mucus-on-repligut-planar-platform-for-research-related-to-gastrointestinal-tract-and-its-associated-disorders-along-with-drug-delivery-studies.html) (35 words)
- [MiniReview: Modeling the Complex Human Intestinal Mucus - Microbiome Nexus In Vitro.  2024, March 28, Journal of Applied Microbiomics - Altis Biosystems](/case-studies-for-lit/minireview-modeling-the-complex-human-intestinal-mucus-microbiome-nexus-in-vitro-2024-march-28-journal-of-applied-microbiomics.html) (35 words)
- [Poster: Characterization of a novel human primary intestinal epithelial monolayer platform in response to a cytokine challenge - Altis Biosystems](/case-studies-for-lit/poster-characterization-of-a-novel-human-primary-intestinal-epithelial-monolayer-platform-in-response-to-a-cytokine-challenge.html) (35 words)
- [Poster: Characterization of biological variability in a stem cell-derived human intestinal epithelium model - Altis Biosystems](/case-studies-for-lit/poster-characterization-of-biological-variability-in-a-stem-cell-derived-human-intestinal-epithelium-model.html) (35 words)
- [Poster: GB004 Exhibits Protective Effects Directly on Epithelial Cells Using Ex Vivo Organoid and Monolayer Cultures - Altis Biosystems](/case-studies-for-lit/poster-gb004-exhibits-protective-effects-directly-on-epithelial-cells-using-ex-vivo-organoid-and-monolayer-cultures.html) (35 words)
- [New England DMDG Summer Symposium - Altis Biosystems](/events-ab/new-england-dmdg-summer-symposium/index.html) (35 words)
- [Poster: Primary Human Small Intestine Monolayers For Assessing Drug-Induced Intestinal Liabilities In Vitro - Altis Biosystems](/case-studies-for-lit/poster-primary-human-small-intestine-monolayers-for-assessing-drug-induced-intestinal-liabilities-in-vitro.html) (35 words)
- [Manuscript: Analysis of Interleukin 8 Secretion by a Stem-Cell-Derived Human Intestinal Epithelial Monolayer Platform - Altis Biosystems](/case-studies-for-lit/manuscript-analysis-of-interleukin-8-secretion-by-a-stem-cell-derived-human-intestinal-epithelial-monolayer-platform.html) (35 words)
- [Great Lakes DMDG meeting - Altis Biosystems](/events-ab/great-lakes-dmdg-meeting/index.html) (35 words)
- [Northeast ADME conference - Altis Biosystems](/events-ab/northeast-adme-conference/index.html) (35 words)
- [Poster: A primary jejunum and primary hepatocyte multi-organ MPS: a promising tool for more predictive studies of human drug ADME and oral bioavailability - Altis Biosystems](/case-studies-for-lit/poster-a-primary-jejunum-and-primary-hepatocyte-multi-organ-mps-a-promising-tool-for-more-predictive-studies-of-human-drug-adme-and-oral-bioavailability.html) (35 words)
- [MPS World Summit - Altis Biosystems](/events-ab/mps-world-summit/index.html) (35 words)
- [IBD Innovate - Altis Biosystems](/events-ab/ibd-innovate/index.html) (35 words)
- [Applied Pharmaceutical Toxicology - Altis Biosystems](/events-ab/applied-pharmaceutical-toxicology/index.html) (35 words)
- [Translational Microbiome - Altis Biosystems](/events-ab/translational-microbiome/index.html) (35 words)
- [Society of Toxicology Annual Meeting - Altis Biosystems](/events-ab/society-of-toxicology-annual-meeting/index.html) (35 words)
- [Events](/events-ab/index.html) (136 words)
- [3D Cell Culture & Organ Modelling 2024 - Altis Biosystems](/events-ab/3d-cell-culture-organ-modelling-2024/index.html) (35 words)
- [AACR - Altis Biosystems](/events-ab/aacr/index.html) (35 words)
- [Next-Gen Microbiome and Probiotics Conference - Altis Biosystems](/events-ab/next-gen-microbiome-and-probiotics-conference/index.html) (35 words)
- [World Organoid Research Day - Altis Biosystems](/events-ab/world-organoid-research-day/index.html) (35 words)
- [Crohn’s and Colitis Congress - Altis Biosystems](/events-ab/crohns-and-colitis-congress/index.html) (35 words)
- [CN-Bio - Altis Biosystems](/case-studies/cn-bio/index.html) (35 words)
- [Altis R&D - Altis Biosystems](/case-studies/altis-rd/index.html) (35 words)
- [Case Studies](/case-studies/index.html) (69 words)
- [Janssen R&D - Altis Biosystems](/case-studies/janssen-rd/index.html) (35 words)
- [Janssen R&D with UNC-Chapel Hill - Altis Biosystems](/case-studies/janssen-rd-with-unc-chapel-hill/index.html) (35 words)
- [Case Studies for Literature TAB](/case-studies-for-lit/index.html) (370 words)
- [How Does Altis Envision the Future of the Pharma Industry?](/how-does-altis-biosystems-envision-the-future-of-the-pharma-biopharma-industry-2.html): Discover how Altis Biosystems envisions the future of the pharma and biopharma industry—exploring trends in human-relevant models, drug development, and scalable innovation using RepliGut® technology. (768 words)

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